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Properties Of N-Hydroxy Succinimide

N-Hydroxysuccinimide (NHS) is used as a catalyst in the zero-length crosslinking of proteins with EDC.N-Hydroxy succinimide functions by stabilizing the protein-EDC intermediate, thus allowing for a more efficient crosslinking reaction. N-Hydroxy Succinimide is a white powder or colorless crystal, easily soluble in many kinds of solvents, resolved in succinic acid and ammonia with water.
N-hydroxysuccinimide activates the elimination of blood originated pigments responsible for dark color and inflammation that causes under eye circles. N-hydroxysuccinimide (NHS) esters have been used for gas-phase conjugation reactions with peptides at nucleophilic sites, such as primary aminesor guanidines, by forming amide bonds through a nucleophilic attack on the carbonyl carbon. The carboxylate has recently been found to also be a reactive nucleophile capable of initiating a similar nucleophilic attack to form a labile anhydride bond. The fragile bond is easily cleaved, resulting in an oxygen transfer from the carboxylate-containing species to the reagent, nominally observed as a water transfer. This reactivity is shown for both peptides and non-peptidic species.
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